46 suited looks like a fold to me OOP without any reads, think this hand is going to be very hard to play read less.

Post flop looks fine, I want to get the chips in ASAP and we block 2/3 of sets.

For my default defense range I have 64s as a defend. My default is somewhere between 30% and 40%, depending on raise size. You only have 25 hands on villain so hard to know if that 13% PFR is really how tight he is. If in fact, he is stealing that tight then idk maybe it's a fold pre, but still think I would defend it.

Post flop: you need about 44% EQ to make the call. If you are up against only 22, 44, 66 and 53s then you are crushed (~15% eq) and should fold, but I doubt that you are. If villain will shove with just one over pair, like TT or JJ, then you get close to a call. If villain will do this with 2 overpairs like TT AND JJ then you have a call. If villain will jam anything more than that, like all overpairs, FDs, pairs + draws, then it is a snap call. So really depends on what you think villain is capable of.

IMO, from what I have seen on the sites I play and videos of coaches playing on iPoker, there are a fair amount of guys that would jam this raise with overpairs a good percentage of the time, so i think I would be snapping this off as well.

Vs standard opponent i think defending around 65% is good. 64s is defo in there but is a hand im 3betting alot of the time. We need to defend this much not to get exploited and we have odds to do it.

This guy is very tight and opens big. So we should take away hands from that range for those two reasons. If he is not folding much v 3bet I think we can call this 64s. We still have 32% raw EQ vs 20% Open range.

Absolutely fine to get it in on the flop. He should never have str8 and few sets.

Pre you need (bet/bet+pot) = 2/6,4=31% eq to call. To make up for a positional disadvantage I think you can play around 30-40 with a mix of 3bets and calls.
As played get it in and be very happy.