And my reply:
" In chipEV situations, 'people' aren't the reason GTO "won't work", we just don't have a GTO solution to poker due to the sheer complexity of the game.
Your second paragraph is of course good strategy, however I disagree with the "That's it" part. I read once that 80% of poker hands are played by 2% of the players[1]. This means that the vast majority of your opponents are going to be regs. Also, because poker is so complex, everyone at the minute is still playing terribly, in absolute terms. If some alien intelligence landed tomorrow and planted a true GTObot in NLHE games, it would crush everybody. Poker is constantly evolving via a process similar to natural selection, i.e. some people go broke, some people make money and stick around. It will constantly evolve, and strategies will rise and fall along the way.
Example: 5 years ago you could easily make a comfortable living with the strategy of playing tight most of the time, but isolating fish and making many small bluffs at them. Then, finally, you show up with the nuts the time when they were ready to call all in. You're right that a GTObot would not do as well against this fish, it would miss out on some of the small pots and not build up as bluffy an image to set up the big payoff, and then it would be bluffing some percentage of the time when the human player would know that the fish is "ready to blow" and is never folding. Obviously don't bluff when you someone is not going to fold.
However, nowadays people that play like that get exploited by other regs, and struggle to find enough fish to get by. They're having to bumhunt harder, maybe waiting at heads up tables and not playing anyone that sits with 100bbs, or playing lower stakes on smaller sites. Knowledge of GTO would help them adjust their strategy to stay ahead of the games. Doing that, they could still be making good money off other regs. E.g. what do you think would happen if a winning 2knl reg dropped down to 100nl for some reason, maybe a prop bet, and played full time in those games without any bumhunting or game selection of any kind. Personally, I think they would win comfortably, because the 100nl regs will be making many mistakes that the 2knl reg is used to exploiting, and due to his greater experience the 2knl reg will be able to anticipate their 1st adjustment, both the adjustment and the timing, quite accurately as well. As I said, the 2knl games are also exploitable in the same way, just nobody has got there yet. To use an example from outside of poker, imagine if Andy Murray could go back in time and play Fred Perry at tennis, I think it would be very one-sided, but back in Fred Perry's day people would have said "you'll never make any money playing Fred Perry at tennis, don't bother", when in reality it was possible to be much better than Fred Perry with a lot of work.
I'm rambling now, but I think the point was that I think it's a very relevant and fruitful area for learning.
[1]Source: Nate Silver's 'The Signal and the Noise'"